This is an advocacy toward our mission statement to create a "Learning Health System" (LHS) will enable data to be rapidly mobilized, continuously analyzed-and the results subsequently shared-to improve health care quality, empower public health and biomedical research, and enable clinicians and patients to collaboratively make better-informed health decisions by having scientific data of what works best in every disease. The book builds upon and is a natural progression from the work we have done together over the years to generate strong bipartisan support for the concept and vision of a Learning Health System.